The current epidemic caused by the novel Coronavirus affects us all and is already changing the world around us. With an increasing count of those affected, it puts forth a lot of questions that can only be answered comprehensively and conclusively by an in-depth review of available data. Due to advances in genomic sequencing and computational methods of data storage, annotation and analysis, genomic data from this outbreak is available in an unprecedented way. This data availability can help change the narrative from opinion-based to data-driven.
As an organization that primarily focuses on human health and wellbeing, we have been working to bring more awareness about data availability and utility from the very start of the COVID-19 outbreak. We already organized several FREE Webinars that were attended by over 500 people. In doing so, we realized that there are a lot of researchers, students and citizen scientists willing to contribute towards research on the coronavirus that affects everyone across the globe. To facilitate the study and help more scientists make the most of the publicly available data and easy to use tools, our team has organized a comprehensive hands-on program, Bioinformatics for Infectious Diseases. This online training is aimed to give everyone an overview and understanding of epidemic diseases and the role omics data plays in our understanding of pathogen evolution, adaptation and pathogenesis.
In a recent blog post on Medium, Elia Brodsky from Pine Biotech shared his views on the role of bioinformatics in modern research and the role of education to help citizen scientists contribute especially in the backdrop of the current COVID-19 pandemic. Our FREE online webinar on COVID-19 Genomics is therefore open for everyone to come and attend. You can watch the recordings of the webinars here and here. Register here for the next free webinar on this topic: https://edu.tbioinfo.com/en-us/covid-19-bioinformatics
To introduce everyone to the virology of epidemic diseases like COVID-19, SARS, MERS, Ebola and even Influenza, we are starting our Bioinformatics for Infectious Diseases from May 4th, 2020. We have written a detailed blog post about the program that you can read here. From our webinar sessions, we also compiled all the questions asked into a blog post that you may find interesting. The following YouTube video will give you a brief overview of the Bioinformatics for Infectious diseases program:
Watch here: https://youtu.be/zZkK98AlvsM
What will you learn by attending this online program?
- Understand Viral Diversity and its role in epidemic Infectious Diseases that keep re-emerging, including zoonotic transmission, transmission between humans and the process of viral and bacterial disease development
- Learn about Bioinformatics Analysis Approaches to study viral genomes and understand relationships between viral strains and haplotypes, finding differences in sequence data and seeing the implications for drug and vaccine design
- Gain hands-on experience by analyzing Curated Datasets from public domain collections, guided by experts with bioinformatics experience and knowledge about virology.
Introduction to bioinformatics basics and data sources.
Session 1: Tuesday, May 4, 2020
Next-generation sequencing: viral genomes in the host transcriptome
- Overview of NGS: reads, sequences, file formats
- alignment, annotation, and non-mapped reads
- Alignment to databases of viral genomes
Session 2: Thursday, May 7, 2020
Multiple Sequence Alignment and Phylogeny
- Comparing sequences (Multiple Sequence Alignment)
- Finding a consensus sequence
- Identifying relationships between sequences (phylogeny, conservation)
Session 3: Tuesday, May 12, 2020
Hands-on session, preparing and running your pipeline:
Multiple sequence alignment of viral genomes and building a phylogenetic tree
- Finding full genome sequences and preparing FASTA files
- Selecting appropriate genomic sequences
- Preparing a full pipeline of MSA and Phylogeny
Session 4: Thursday, May 14, 2020
Q&A and DISCUSSION of pipeline results:
- Workflows: what to do if we have FASTA/FASTQ files?
- Which databases to use: Detection of viral genomes by mapping on databases
- Interpretation of Phylogenetic Analysis: Evolutionary relationships between genomes, evolutionary time
Part 2: Genomics and Virology:
How can bioinformatics be used to study pandemics?
Session 5: Tuesday, May 19, 2020
From Infection to Pandemic: Viral Adaptation
- Hosts and origins
- Cell entry and tissue tropism
Session 6: Thursday, May 21, 2020
Symptom severity: Disease progression and outcomes
- Viral proteins
- Immune evasion
Session 7: Tuesday, May 26, 2020
EXAMPLE: The origin of human infection with MERS, SARS, and SARS-2 pandemics
Session 8: Thursday, May 28, 2020
Rate of Mutation – mutation variant types
- Point mutations, substitutions, insertions
- Mutation types (synonymous/nonsynonymous; sense/missense)
- Mutation rate and fitness (frequency, entropy, conservation)
Session 9: Tuesday, June 2, 2020
Mutation Annotation & Significance for analysis
- codon/amino-acid and chemical properties
- Location on genome and protein function
Session 10: Thursday, June 4, 2020
- Protein-protein interaction and host response
- Immune response (adaptive, innate)
- Vaccine design: factors for consideration
Case studies we will utilize in this program:
- Coronaviruses and the recent COVID-19 epidemic
- EBOLA outbreaks over the last decade: emerging diseases
- Flu and other respiratory disorders: challenges with vaccines and antivirals
- Tuberculosis: bacterial chronic diseases and antibiotic resistance
CONCLUSION and OUTCOMES:
In this program, we will learn about important principles of bioinformatics in application to virology, including:
Use of bioinformatics in virology
- Methods of analysis
- Databases and references
- Raw data types and repositories
Important factors for vaccine design
- Exposed parts of viral proteins
- Vaccine types: protein-based, virus-based
- Novel approaches to rapid-response vaccines: interference
Important factors for antivirals
- Prevention of cell entry
- Inhibition of replication
- Toxicity, specificity
- Solubility, permeability
Alignment, annotation, characterization of mutations, GWAS, phylogenetic analysis, RNA-seq
Join the program today and start this research journey with us.
Registration Link: https://edu.tbioinfo.com/bioinformatics-for-infectious-diseases-2020
The Registration cost is $150 USD. Up until April 24th, we are offering a discount of 30%. So you pay only $105 USD for access to the program including courses and access to T-Bio Info Server for the duration of the program.
You can also take 30% off using the code “VIRAL30” during checkout before April 24th, 2020.
We know a lot of students from high school to graduate level, are interested in learning more about COVID-19 and do their bit to contribute towards research. To help the young generation of students and future researchers to learn, we offer student scholarships that are available on request. We are also offering group discounts to faculty and students who are interested in joining the program from the same university or college.
For any queries related to discounts, please contact: email@example.com