Enterovirus D68 and Acute flaccid myelitis in Kids
Acute flaccid myelitis (AFM) is a severe neurogenic disease in children caused by Enterovirus D68 (EV-D68) virus. AFM is a polio-like illness defined by the acute onset of flaccid paralysis in the setting spinal MRI demonstrating a longitudinal lesion in the gray matter of the cord. In this project, we will try to understand the evolutionary relationship between strains of different outbreaks of EV-D68. Here, we will try to find out whether EV-D68 strains from the different outbreaks at different time points (2014, 2016 and 2018) are the same or different based on phylogenetic analysis of NGS data.
Project Features
- Lectures 16
- Quizzes 2
- Students 18
- Certificate No
- Assessments Yes
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Project Overview
In this section, you will get Brief overview of the project
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Enterovirus D68 and Acute flaccid myelitis: Introduction
In this section, we will learn about Enterovirus D68virus, and disease caused by it, i.e. Acute Flaccid Myelitis
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Phylogenetic Methods
In this section, we will learn about different phylogenetic reconstruction tree methods
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Phylogenetic Analysis of Enterovirus D68 strains
In this section, we will learn about how we can perform phylogenetic analysis
- Datasets and Data Upload for Phylogenetic Analysis
- Phylogenetic Analysis by APE method
- Phylogenetic Analysis by BEAST-Coalescent Size Method
- Phylogenetic Analysis by BEAST-Yule Process Method
- Phylogenetic Analysis by BEAST-Birth death Process Method
- Multiple Sequence Alignment (MSA)
- Conclusion
- Assignment
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References
