Epigenetics refers to mechanisms of gene expression regulation that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation.
Epigenetic regulations play an important role in a variety of human disorders and diseases. In addition, age, environment, lifestyle, and other factors influence epigenetic states.
Epigenetic regulation of gene expression has been linked to discrete mechanisms that affect the stability, folding, positioning, and organization of DNA. The most studied of these mechanisms includes DNA methylation and chromatin remodeling, which work synergistically to organize the genome into transcriptionally active and inactive zones.
To better understand the bioinformatics approaches to studying the epigenetic changes in cells, it is firts important to understand the biology and the molecular assays that are used in researching these regulatory mechanisms.
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- Duration 50 hours
- Skill level Intermediate
- Language English
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