Introduction to Genomics
Introduction to Genomics Course Description:
The Introduction to Genomics course is dedicated to the subject of genomic data and the use of Next Generation Sequencing as a tool to analyze and understand the information contained within a genome. DNA has a double-stranded structure giving it a stable and therefore suitable molecular structure for information storage. The mechanism of DNA replication and the transcription of expressed genes depend on the code contained within a DNA molecule. Changes in a genomic sequence can have dramatic consequences on the resulting protein generated when a gene is expressed. In this review, we will be covering topics that include commonly studied DNA variation (substitutions, insertions and deletions) and looking at a few examples of how DNA variation can affect health, disease and treatment (reference). At the end, you will have the option to apply the acquired understanding to one of our prepared projects or a project of your own.
In a subsequent course, Genomics 1, we will also discuss the analytical challenges associated with data preparation, analysis and interpretation of sequencing results.
Questions we will try to answer:
- What is DNA variation and what types of variation are there?
- What DNA elements are being studied for variation?
- What types of genomic information exist and can be analyzed?
Terms you will learn about:
- Base pair
- Point Mutation (insertion, deletion, and substitution)
- Variant calling
- Germline mutation
- Somatic mutation
- Lectures 7
- Quizzes 2
- Duration 50 hours
- Skill level All levels
- Language English
- Students 1275
- Certificate Yes
- Assessments Yes
DNA structure and variants
Types of Genome Sequencing
DNA Basics and Sequencing
The course is well planned. It has covered a lot and has helped refreshed my understand this aspect; particularly the sequencing techniques with their applications. However, some explanations were not concise perhaps due to shift in wordings. For instance, I found it difficult understanding aspect on GRCh38 vs GRCh 37 as well as how to measure the length of base pairs. This had made getting through the quizzes very tough. It will suggest inclusion of video/s for course for more demonstrations.
The course content is explanatory for beginners and it offers great insights into the field of genomics.
I would like two retake this course again, pls help me out as i cant find the means to
Abu Aishatu 15
This course is really precise and full of information. It's really an introduction that even one who has no idea of cell biology could come out with something. Good work
it is really nice course, but why the certificate web is not working? can you help me for that