Introduction to Genomics
Introduction to Genomics Course Description:
The Introduction to Genomics course is dedicated to the subject of genomic data and the use of Next Generation Sequencing as a tool to analyze and understand the information contained within a genome. DNA has a double-stranded structure giving it a stable and therefore suitable molecular structure for information storage. The mechanism of DNA replication and the transcription of expressed genes depend on the code contained within a DNA molecule. Changes in a genomic sequence can have dramatic consequences on the resulting protein generated when a gene is expressed. In this review, we will be covering topics that include commonly studied DNA variation (substitutions, insertions and deletions) and looking at a few examples of how DNA variation can affect health, disease and treatment (reference). At the end, you will have the option to apply the acquired understanding to one of our prepared projects or a project of your own.
In a subsequent course, Genomics 1, we will also discuss the analytical challenges associated with data preparation, analysis and interpretation of sequencing results.
Questions we will try to answer:
- What is DNA variation and what types of variation are there?
- What DNA elements are being studied for variation?
- What types of genomic information exist and can be analyzed?
Terms you will learn about:
- Base pair
- Point Mutation (insertion, deletion, and substitution)
- Variant calling
- Germline mutation
- Somatic mutation
- Lectures 7
- Quizzes 2
- Duration 50 hours
- Skill level All levels
- Language English
- Students 645
- Certificate Yes
- Assessments Yes
DNA structure and variants
Types of Genome Sequencing
An excellent course on genomics
This course provides an in depth knowledge on different areas of genomics. It is really helpful in understanding the different concepts related to genomics
A wonderful course to understand genomics
The course is wonderfully designed to understand the basics of WGS and WES which easily establishes a great foundation to learn more about genomics and WES&WGS...
A fascinating beginning into the world of genomics
The course describes very vividly about the basics of genomics in a much understandable manner . The contents are designed in a very precise manner so that one can get a very clear concept about the topics.
Well written course
This course Introduction to Genomics has been written in such a way that students can understand the basics of genetics,i.e,DNA structure,gene and also the concepts like Whole Genome Sequencing and Whole Exome Sequencing easily.The suggested readings were also of immense help while reading the lectures.
A wonderful course to start learning Genomics
The Genomics Course starts with a generic introduction comprising the basics of the central dogma, the pivotal concept of Molecular Biology. The most important thing about Genomics study is understanding the Variation that occurs in a Genome. Hence the course starts from explaining the structure of the DNA and moving over to origin and the analysis of the variations that occur. At the heart of the course there is the pipeline, server.t-bio, where for each algorithm, there is a pop-up that describes the algorithm. After the bare essential theories are over, the turn to use the Pipelines (t-bio server) comes. Small informative videos to give a visual understanding of how to run the Pipeline is a perfect process to guide the newbie and the experienced as well. The best thing about the course is that it brings out the perfect flavour of a how a pipeline should be used and leave the ground open for further explorations by the participant to click and use the other sets of algorithms at the “t-bio server” on “Data Pre-Processing”, “Mapping”, “Variant Calling”, “Annotation”. All these individual classes have on-click information popups. Subsequent to the execution of the sample pipeline comes the analysis of the results, and here also the course leaves the ground open for the initiated participant for exploring more beyond what is being explained. It also provides a link to a carefully developed sample project using Machine Learning present at the edu.t-bio.info site. One cannot deny the importance of Quiz, which always benchmark the learning path. The Genomics course also have a list of references at the end for further reading.