Introduction to Genomics
Introduction to Genomics Course Description:
The Introduction to Genomics course is dedicated to the subject of genomic data and the use of Next Generation Sequencing as a tool to analyze and understand the information contained within a genome. DNA has a double-stranded structure giving it a stable and therefore suitable molecular structure for information storage. The mechanism of DNA replication and the transcription of expressed genes depend on the code contained within a DNA molecule. Changes in a genomic sequence can have dramatic consequences on the resulting protein generated when a gene is expressed. In this review, we will be covering topics that include commonly studied DNA variation (substitutions, insertions and deletions) and looking at a few examples of how DNA variation can affect health, disease and treatment (reference). At the end, you will have the option to apply the acquired understanding to one of our prepared projects or a project of your own.
In a subsequent course, Genomics 1, we will also discuss the analytical challenges associated with data preparation, analysis and interpretation of sequencing results.
Questions we will try to answer:
- What is DNA variation and what types of variation are there?
- What DNA elements are being studied for variation?
- What types of genomic information exist and can be analyzed?
Terms you will learn about:
- Base pair
- Point Mutation (insertion, deletion, and substitution)
- Variant calling
- Germline mutation
- Somatic mutation
- Lectures 7
- Quizzes 2
- Duration 50 hours
- Skill level All levels
- Language English
- Students 658
- Certificate Yes
- Assessments Yes
DNA structure and variants
Types of Genome Sequencing
DNA Basics were cleared; Understanding sequencing was made easy
In the first section "DNA structure and variants" helped me revise my DNA biology basics. One has to have the basic idea of DNA biology cleared to swim through this part. The references deepened my understanding. The second part "Types of Sequencing" was a bit new to me. Yet the way it was all explained with concept and easy examples along with relevant references, one can move from here to confidently deal with sequencing jargons further ahead. The quizzes were well thought.
An excellent course on genomics
This course provides an in depth knowledge on different areas of genomics. It is really helpful in understanding the different concepts related to genomics
A wonderful course to understand genomics
The course is wonderfully designed to understand the basics of WGS and WES which easily establishes a great foundation to learn more about genomics and WES&WGS...
A fascinating beginning into the world of genomics
The course describes very vividly about the basics of genomics in a much understandable manner . The contents are designed in a very precise manner so that one can get a very clear concept about the topics.
Well written course
This course Introduction to Genomics has been written in such a way that students can understand the basics of genetics,i.e,DNA structure,gene and also the concepts like Whole Genome Sequencing and Whole Exome Sequencing easily.The suggested readings were also of immense help while reading the lectures.