Introduction to Genomics
This course is dedicated to the subject of genomics and the use of Next Generation Sequencing as a tool to analyze and understand the information contained within a genome. DNA has a double-stranded structure giving it a stable and therefore suitable molecular structure for information storage. The mechanism of DNA replication and the transcription of expressed genes depend on the code contained within a DNA molecule. Changes in a genomic sequence can have dramatic consequences on the resulting protein generated when a gene is expressed. In this review, we will be covering topics that include commonly studied DNA variation (substitutions, insertions and deletions) and looking at a few examples of how DNA variation can affect health, disease and treatment. At the end, you will have the option to apply the acquired understanding to one of our prepared projects or a project of your own.
We will also discuss the analytical challenges associated with data preparation, analysis and interpretation of sequencing results. These considerations will be relevant for our next courses where you will use this background to logically evaluate your own sequencing results.
Questions we will try to answer:
- What is DNA variation and what types of variation are there?
- What DNA elements are being studied for variation?
- What types of genomic information exist and can be analyzed?
Terms to Know:
- Base pair
- Point Mutation (insertion, deletion, and substitution)
- Variant calling
- Germline mutation
- Somatic mutation
- Lectures 7
- Quizzes 2
- Duration 50 hours
- Skill level All levels
- Language English
- Students 509
- Certificate Yes
- Assessments Yes
DNA structure and variants
Types of Genome Sequencing
Perfect Introduction to Genomics concept!
Introduction to Genomics is a very basic and essential course which lucidly lays down the basic details of the most valuable unit of life – The DNA. It deals with the various types of sequencing techniques like – Targeted sequencing, Exome sequencing and Whole Genome sequencing. It is a wonderful experience to learn about them and also correctly differentiate between them.
This module briefs very well on what Genome and Genomics is, and how we do studies related to it.