Tuberculosis Infection and Treatment: Finding Drug Resistant Variants by GWAS
One-third of the world’s population has been infected with tuberculosis (TB). TB is caused by Mycobacterium tuberculosis (Mtb). The disease has severe symptoms including chronic cough, blood present in the sputum, and weight loss. The principal cause of tissue destruction from Mtb infection is related to an organism’s ability to incite intense host immune reactions to antigenic cell wall proteins. Drug resistance in mycobacterium tuberculosis is one of the major concerns worldwide. It is important to identify the variants that responsible for drug resistance in TB. Genotypic resistance mostly results from single nucleotide polymorphisms (SNPs), insertions or deletions (indels) and to a certain extent, deletions in genes that encode drug targets or drug metabolizing enzymes within the bacilli. Resistance can result in failure to metabolize prodrugs to active forms, poor drug permeability, increased efflux or modifications in the drug-target structure that result in the inhibition of effective drug binding. This project is designed to identify those genes that are associated with Drug resistance implementing GWAS approach.
- Lectures 13
- Quizzes 2
- Duration 50 hours
- Skill level All levels
- Language English
- Students 12
- Certificate No
- Assessments Yes
In this section, you will get overview of this project.
In this section, you will get overview of tuberculosis, it's causing agent, drugs and drug resistance mutations.
In this section, you will get an overview about the different GWAS methods, including GEMMA, PLINK, and Slope.
GWAS study: Drug Resistance Analyses
In this section, you will learn how we can study drug resistance in tuberculosis implementing different GWAS methods.