Immunology

Cancer is an important challenge for which personalized molecular medicine shows great promise. Recent advances in immunotherapy and genetic testing have been proposed to help transform care from one-size-fits-all to a highly specialized range of options that could be adapted to fit an individual’s molecular features. However, we are still far from understanding and navigating cancer. In fact, many promising research projects that reveal new targets and promising strategies that work on animal models fail in clinical trials. While generating data has been increasingly accessible, the challenge is now in integration and extracting insights from this data. A multi-omics approach based on big data analyses could lead to substantial advances in cancer treatment.

Real Projects from High Impact Publications

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Cutting Edge Research

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From Basic Biology to Application

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Immunology

Researchers have started to study immune system utilizing data-driven prediction methods and have made significant progress utilizing big data. By utilizing Bioinformatics, new discoveries about the immune response, pathogen interactions, as well as T and B cell epitope predictions can be made. The characterization of these responses will be crucial for understanding the difference in cell activity of individuals who are chronically exposed vs. short term to antigens. Additionally, researchers are trying to better understand the relationship between genetic predispositions to autoimmune diseases and environmental perturbations on susceptibility. The elucidation of these pathways, characterization of cell types and understanding environmental influence will greatly benefit clinicians in the future, and will revolutionize drug efficacy and screening procedure.

To encourage more students and researchers to make use of the potential and power afforded by big biomedical data, the Pine Biotech team designed a series of lessons that focus on immunology, with practical, hands-on projects that allow students to practice analyses with data adapted from real datasets.

The course will cover some of the important aspects of immunology:

  • Molecular components of the inflammatory cascade
  • Characterization of epitope responses and drug efficacy
  • Microenvironment of immune cells: cytokines, T cells, B cells, memory cells, TLR,etc
  • The bacteria mechanism of entry and how it is involved in development and prevention of certain disease types
  • The interplay with susceptibility genes and the environmental factors leading to adverse events
  • Clinical Data and the future of disease prevention/screening
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Courses

Course 1

Transcriptomics 1

Molecular biology is a vast and eclectic field, composed of many branches and subdisciplines. Molecular biologists study a broad spectrum of topics relating to the molecular regulation of cell biology, from DNA and RNA, to protein expression and protein-protein interactions. A dominant theme in molecular biology is how variation in nucleic acids (genotype) affects the biology of organisms (phenotype). The 2 main types of nucleic acid variation are:

  • gene variation at the level of DNA (genomics)
  • variation in gene expression (transcriptomics)
Commitment : 1-4 hours/week
Subtitles : English, French, Chinese (Simplified), Greek, Italian, Portuguese (Brazilian), Vietnamese, Russian, Turkish, Hebrew

Course 2

Transcriptomics 2

Molecular biology is a vast and eclectic field, composed of many branches and subdisciplines. Molecular biologists study a broad spectrum of topics relating to the molecular regulation of cell biology, from DNA and RNA, to protein expression and protein-protein interactions. A dominant theme in molecular biology is how variation in nucleic acids (genotype) affects the biology of organisms (phenotype). The 2 main types of nucleic acid variation are:

  • gene variation at the level of DNA (genomics)
  • variation in gene expression (transcriptomics)
Commitment : 1-4 hours/week
Subtitles : English, French, Chinese (Simplified), Greek, Italian, Portuguese (Brazilian), Vietnamese, Russian, Turkish, Hebrew

Course 3

Metagenomics 1

Molecular biology is a vast and eclectic field, composed of many branches and subdisciplines. Molecular biologists study a broad spectrum of topics relating to the molecular regulation of cell biology, from DNA and RNA, to protein expression and protein-protein interactions. A dominant theme in molecular biology is how variation in nucleic acids (genotype) affects the biology of organisms (phenotype). The 2 main types of nucleic acid variation are:

  • gene variation at the level of DNA (genomics)
  • variation in gene expression (transcriptomics)
Commitment : 1-4 hours/week
Subtitles : English, French, Chinese (Simplified), Greek, Italian, Portuguese (Brazilian), Vietnamese, Russian, Turkish, Hebrew

Projects

Asthma T-cell histone modification and transcriptome (GWAS)

(Boris, Julia P, Yulia G, Alexei)

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Immunology, specificity of TCR receptors

(Julia P. and Avi are responsible)

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Arthritis??

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Microbiome Project

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Certificate

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Pilots and Advisors

Dr. Kasthuri Kannan

(NYU)

Dr. Lucio Miele

(LSU)

Dr. Dario Ghesi

(UNO)

Project Team

Dr. Ronald Ferucci

Julia Panov

Sahil Sethi

FAQ’s

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Fusce et pretium purus. Sed eu tincidunt ipsum, et ullamcorper erat. Proin congue consect sdfetur dui et convallis. Mauris accu msan lectus in diam pretium, ac aliquet tellus Suspendisse vel lectus eu magna commodo aliquam. Nunc nec lorem orci. Pelle ntesque facilisis lacus ac velit imperdiet, sit amet accumsan ex pellentesque. Nullam malesuada ligula vel magna vulputate cons equat. Fusce nec rhoncus sem, a varius risus. Donec tristique rhoncus metus, ut venenatis lacus porta sit amet. Nulla facilisi. Sed et magna mauris. Aliquam interdum eu dolor quis ultricies.

Fusce et pretium purus. Sed eu tincidunt ipsum, et ullamcorper erat. Proin congue consect sdfetur dui et convallis. Mauris accu msan lectus in diam pretium, ac aliquet tellus Suspendisse vel lectus eu magna commodo aliquam. Nunc nec lorem orci. Pelle ntesque facilisis lacus ac velit imperdiet, sit amet accumsan ex pellentesque. Nullam malesuada ligula vel magna vulputate cons equat. Fusce nec rhoncus sem, a varius risus. Donec tristique rhoncus metus, ut venenatis lacus porta sit amet. Nulla facilisi. Sed et magna mauris. Aliquam interdum eu dolor quis ultricies.

Fusce et pretium purus. Sed eu tincidunt ipsum, et ullamcorper erat. Proin congue consect sdfetur dui et convallis. Mauris accu msan lectus in diam pretium, ac aliquet tellus Suspendisse vel lectus eu magna commodo aliquam. Nunc nec lorem orci. Pelle ntesque facilisis lacus ac velit imperdiet, sit amet accumsan ex pellentesque. Nullam malesuada ligula vel magna vulputate cons equat. Fusce nec rhoncus sem, a varius risus. Donec tristique rhoncus metus, ut venenatis lacus porta sit amet. Nulla facilisi. Sed et magna mauris. Aliquam interdum eu dolor quis ultricies.

Fusce et pretium purus. Sed eu tincidunt ipsum, et ullamcorper erat. Proin congue consect sdfetur dui et convallis. Mauris accu msan lectus in diam pretium, ac aliquet tellus Suspendisse vel lectus eu magna commodo aliquam. Nunc nec lorem orci. Pelle ntesque facilisis lacus ac velit imperdiet, sit amet accumsan ex pellentesque. Nullam malesuada ligula vel magna vulputate cons equat. Fusce nec rhoncus sem, a varius risus. Donec tristique rhoncus metus, ut venenatis lacus porta sit amet. Nulla facilisi. Sed et magna mauris. Aliquam interdum eu dolor quis ultricies.

Fusce et pretium purus. Sed eu tincidunt ipsum, et ullamcorper erat. Proin congue consect sdfetur dui et convallis. Mauris accu msan lectus in diam pretium, ac aliquet tellus Suspendisse vel lectus eu magna commodo aliquam. Nunc nec lorem orci. Pelle ntesque facilisis lacus ac velit imperdiet, sit amet accumsan ex pellentesque. Nullam malesuada ligula vel magna vulputate cons equat. Fusce nec rhoncus sem, a varius risus. Donec tristique rhoncus metus, ut venenatis lacus porta sit amet. Nulla facilisi. Sed et magna mauris. Aliquam interdum eu dolor quis ultricies.