Bioinformatics for Precision Medicine
Precision medicine is changing the way we understand, diagnose and treat major life-threatening diseases. The transformation is driven by high-throughput molecular data from patients, animal models, and large-scale experiments.
In this program, we will explore how the various -omics data types can be analyzed to understand the basic biology associated with viruses & hosts, cancer onset & development and outcomes and see how large-scale clinical trials and experiments provide an opportunity to improve precision medicine. In the later part of the program, we will learn about virology and immunology and the use of bioinformatics for infectious disease research, diagnostics as well as drug and vaccine development.
Upcoming Events
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16June
Bioinformatics in Translational Oncology Research
Cancer biology: changes in organs, tissues, and cells, Molecular factors in tumor development and metastasis, Clinical and molecular data in oncology studies, Analyzing the...
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18June
Next Generation Sequencing: Analysis of DNA Variation
Processing (germline and somatic mutations) Analysis (mapping, detecting variants) Interpretation (variant types and significance)
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23June
Processing Next Generation Sequencing Data
Quality Control and the role of pre-processing, Mapping strategies: alignment to transcriptome or genome Quantification and Visualization of Gene Expression
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25June
Machine Learning for Gene Expression Data
Data exploration using dimensionality reduction and clustering, Classification and discriminant analysis for labeled datasets, Unsupervised & Supervised Machine Learning
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30June
Oncology Data sources: Raw data and Public databases
National Center for Biotechnology Information (NCBI)Sequence Read Archive (SRA), Gene Expression Omnibus (GEO)The Cancer Genome Atlas (TCGA), COSMIC
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02July
Next-generation sequencing – viral genomes in the host transcriptome
Overview of NGS: reads, sequences, file formats, alignment, annotation, and non-mapped reads, Alignment to databases of viral genomes
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07July
Multiple Sequence Alignment and Phylogeny
Multiple sequence alignment and Phylogenetic Analysis, Preparation of data: assembled genome sequences, Selecting appropriate genomic sequences for a full pipeline
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09July
Q&A Session and Discussion of pipeline results
The logic behind various Workflows and Pipelines, Finding and using the right References & Databases Approaches to Interpretation of Visual Outputs
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14July
From Infection to Pandemic: viral adaptation
Example Project: the origin of Coronavirus pandemics: MERS, SARS, and SARS-2 outbreaks
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16July
Host-pathogen interaction
Interaction between pathogen and host response, Analysis of gene expression to capture immune responses, Implications for vaccine design: factors for consideration.
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